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ea0041ep617 | Endocrine tumours and neoplasia | ECE2016

Dual inhibition of PI3K and mTORC1/C2 by PKI-587 (PF-05212384) as a promising therapeutic option for pulmonary neuroendocrine tumor disease

Broker Vanessa , Freitag Helma , Christen Friederike , Briest Franziska , Siegmund Britta , Grabowski Patricia

Background: Pulmonary neuroendocrine neoplasms are heterogeneous in their clinical behavior and therapeutic options are still not satisfactory. The ‘crosstalk’ of different signaling pathways in NEN cells appears to be more complex as known already. PKI-587 is a highly potent novel dual inhibitor of PI3K and mTORC1/C2.Aim: Therefore, we assessed the effects of PKI-587 in different pulmonary NEN cell lines compared to the established mTORC1 inhi...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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